Pfizer’s Profit Jumps on Sale of Nutrition Business

Pfizer Inc.'s fourth-quarter profit more than quadrupled, despite competition from generic drugs hurting sales of Lipitor and other medicines, because of a $4.8 billion gain from selling its nutrition business. The drugmaker's profit and sales both beat Wall Street expectations.

The world's biggest drugmaker said Tuesday that its net income was $6.32 billion, or 85 cents per share, up from $1.44 billion, or 19 cents per share, a year earlier.

Excluding the windfall from selling its nutrition business to Nestle SA for $11.5 billion on Nov. 30, and a total of $888 million for restructuring, legal and other one-time items, the Viagra maker would have had a profit of $3.51 billion, or 47 cents per share. That's 3 cents more than analysts surveyed by FactSet were expecting.

In early trading, the New York-based company's shares rose 26 cents, or 1 percent, to $27.10.

Revenue fell 7 percent to $15.1 billion, mainly due to generic competition to cholesterol blockbuster Lipitor. Analysts expected $14.35 billion.

"Overall, a good quarter driven by the revenue beat," BernsteinResearch analyst Dr. Timothy Anderson wrote to investors, calling Pfizer's 2013 financial forecast "a bit underwhelming."

Pfizer said it expects 2013 earnings per share of $2.20 to $2.30, excluding one-time items, and revenue of $56.2 billion to $58.2 billion. Analysts are expecting $2.28 per share and revenue of $57.55 billion.

Lipitor, which had reigned as the world's top-selling drug ever for nearly a decade, got U.S. generic competition in December 2011 and now has generic rivals in many major markets. The pill had been bringing Pfizer nearly $11 billion a year before then, down from its peak of $13 billion a year.

In the fourth quarter, Lipitor sales plunged 91 percent in the U.S. and 71 percent worldwide, to $584 million. A dozen other medicines also had lower sales due to generic competition.

Altogether, generic competition reduced prescription drug revenue by more than $2.1 billion. Unfavorable currency exchange rates lopped off another 2 percent, or $271 million.

However, several key newer drugs had double-digit sales increases, including fibromyalgia and pain treatment Lyrica, at $1.13 billion, painkiller Celebrex at $750 million, and the Prevnar 13 vaccine against meningitis and other pneumococcal infections, at $993 million. Viagra was up 6 percent at $553 million.

Altogether, Pfizer's prescription drug revenue fell 9 percent in the quarter, to $12.89 billion. The division was led by sales of primary-care medicines, which totaled $3.83 billion. Still, that was down 29 percent as Lipitor's sales in the two biggest markets, the U.S. and Japan, where shifted into the established products category. That segment, which markets off-patent drugs still popular in many countries, posted a 3 percent rise in revenue, to $2.37 billion.

Specialty products, such as Enbrel for psoriasis and rheumatoid arthritis, and hemophilia treatments Refacto AF and Benefix, had revenue dip 4 percent, to a combined $3.67 billion. Sales in emerging markets such as China and India jumped 17 percent, to $2.65 billion, while sales of cancer drugs, a newer focus for Pfizer, rose 9 percent to $370 million.

The animal health business saw revenue increase 6 percent, to $1.17 billion. Pfizer is set to sell about a 20 percent share in the business, called Zoetis, in an initial public offering on Friday.

The consumer health business saw revenue jump 16 percent, to $936 million, due to strong growth of Advil pain reliever and Centrum vitamins.

He said Pfizer will soon launch two new medicines, rheumatoid arthritis treatment Xeljanz and — with partner Bristol-Myers Squibb Co. — potential blockbuster Eliquis, for preventing heart attacks and dangerous clots in patients with the irregular heartbeat atrial fibrillation. CEO Ian Read said Pfizer's mid- to late-stage drug pipeline "continues to strengthen with key potential opportunities," including drugs for advanced breast cancer and three other types of cancer, one for high cholesterol and a meningococcal B vaccine for adolescents and young adults.

For the full year, net income was $14.57 billion, or $1.94 per share. That was down from $10.01 billion, or $1.27 per share, in 2011. Revenue totaled $58.99 billion, down 10 percent from $65.26 billion in 2011, before generic competition slashed sales of Lipitor and schizophrenia drug Geodon.

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Senators Agree on Blueprint for Immigration

J. Scott Applewhite/Associated Press

Senators Lindsey Graham, left, and Charles E. Schumer, shown in 2011, are two of the eight lawmakers behind the proposal.

A bipartisan group of senators has agreed on a set of principles for a sweeping overhaul of the immigration system, including a pathway to American citizenship for 11 million illegal immigrants that would hinge on progress in securing the borders and ensuring that foreigners leave the country when their visas expire.

The senators were able to reach a deal by incorporating the Democrats’ insistence on a single comprehensive bill that would not deny eventual citizenship to illegal immigrants, with Republican demands that strong border and interior enforcement had to be clearly in place before Congress could consider legal status for illegal immigrants.

Their blueprint, set to be unveiled on Monday, will allow them to stake out their position one day before President Obama outlines his immigration proposals in a speech on Tuesday in Las Vegas, in the opening moves of what lawmakers expect will be a protracted and contentious debate in Congress this year.

Lawmakers said they were optimistic that the political mood had changed since a similar effort collapsed in acrimony in 2010. Senator John McCain, Republican of Arizona and one of the negotiators, said he saw “a new appreciation” among Republicans of the need for an overhaul.

“Look at the last election,” Mr. McCain said Sunday morning on ABC’s “This Week With George Stephanopoulos.” “We are losing dramatically the Hispanic vote, which we think should be ours.” The senator also said he had seen “significant improvements” in border enforcement, although “we’ve still got a ways to go.”

He added, “We can’t go on forever with 11 million people living in this country in the shadows in an illegal status.”

According to a five-page draft of the plan obtained by The New York Times on Sunday, the eight senators — including Mr. McCain; Charles E. Schumer, Democrat of New York; and Lindsey Graham, Republican of South Carolina — have agreed to address the failings of the immigration system in one comprehensive measure, rather than in smaller pieces, and to offer a “tough, fair and practical road map” that would eventually lead to a chance at citizenship for nearly all of the immigrants here illegally.

“We on the Democratic side have said that we are flexible and we want to get a bill,” Mr. Schumer told reporters in New York on Sunday. “But there’s a bottom line, and that’s a path to citizenship for the 11 or so million people who qualify. We’ve made great, great progress with our Republican colleagues.”

Under the senators’ plan, most illegal immigrants would be able to apply to become permanent residents — a crucial first step toward citizenship — but only after certain border enforcement measures had been accomplished.

Among the plan’s new proposals is the creation of a commission of governors, law enforcement officials and community leaders from border states that would assess when border security measures had been completed. A proposal would also require that an exit system be in place for tracking departures of foreigners who entered the country through airports or seaports, before any illegal immigrants could start on a path to citizenship.

The lawmakers intend for their proposals to frame the debate in the Senate, which is expected to take up immigration this spring, ahead of the House of Representatives. Compared with an immigration blueprint from 2011 that White House officials have said is the basis for the president’s position, the senators’ proposals appear to include tougher enforcement and a less direct path for illegal immigrants than Mr. Obama is considering.

In a parallel effort, a separate group of four senators will introduce a bill this week dealing with another thorny issue that is likely to be addressed in a comprehensive measure: visas for legal immigrants with advanced skills in technology and science. The bill, written primarily by Senator Orrin G. Hatch of Utah, a Republican, and Senator Amy Klobuchar of Minnesota, a Democrat, would nearly double the number of temporary visas, known as an H-1B, available each year to highly skilled immigrants. It would also free up more permanent resident visas, known as green cards, so those immigrants could eventually settle in the United States and go on to become citizens.

This article has been revised to reflect the following correction:

Correction: January 28, 2013

Because of an editing error, an earlier version of this article misidentified the journalist who interviewed Senators Robert Menendez and John McCain on “This Week With George Stephanopoulos” on ABC. It was Martha Raddatz, not Mr. Stephanopoulos.

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Apple reportedly prepping new 128GB fourth-gen iPad

It isn’t the “next big thing” Apple (AAPL) investors are said to be waiting for as the company’s share price continues to plummet, but Apple is reportedly prepping a new iPad that will be its first iOS device to pack more than 64GB of storage. 9to5Mac reports that Apple has a new fourth-generation iPad SKU that will soon hit the shelves at one of its retail partners’ stores. Details are slim but the site says its source noted the presence of the word “ultimate” next to the new iPad’s description in the retailer’s system, leading 9to5Mac to speculate that the new model will feature 128GB of internal memory, adding a fourth storage option to Apple’s full-size iPad arsenal. The 128GB iPad listed in the retailer’s system reportedly features both Wi-Fi and cellular connectivity options. A purported image from the “high-profile” retailer’s inventory system follows below.

[More from BGR: Driverless cars could be the big thing that vaults Google over Apple]

This article was originally published on BGR.com

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'Argo' on a roll with big win at SAG Awards

LOS ANGELES (AP) — A few weeks ago, the Oscar race looked wide open. The stately, historical "Lincoln" seemed like the safe and likely choice, with the provocative "Zero Dark Thirty" and the quirky and inspiring "Silver Linings Playbook" very much in the mix for the Academy Award for best picture.

But now, an "Argo" juggernaut — an "Argo"-naut, if you will — seems to be rolling along and gathering momentum as we head toward Hollywood's top prize.

The international thriller from director Ben Affleck, who also stars as a CIA operative orchestrating a daring rescue during the 1979 Iranian hostage crisis, received the top honor of best ensemble cast in a movie at Sunday night's Screen Actors Guild Awards, their equivalent of the best-picture Oscar. It's a decent indicator of eventual Academy Awards success, with the two matching up about half the time.

The film, which also stars John Goodman and Alan Arkin as Hollywood veterans who help stage a fake movie as a cover, has received nearly unanimous critical raves and has proven to be a box-office favorite, as well, grossing nearly $190 million worldwide.

But "Argo" also won the Producers Guild of America Award on Saturday night, which is an excellent Oscar predictor, and it earned best picture and director statues from the Golden Globes two weeks earlier. The Directors Guild of America Awards next Saturday will help crystallize the situation even further.

The one tricky thing at work here: Affleck surprisingly didn't receive an Academy Award nomination in the director category, which most often goes hand in hand with best picture. (There are nine best-picture nominees but only five slots for directors.) Only once in modern times has a film won best picture without a directing nomination: 1989's "Driving Miss Daisy." The other two times came in the show's early years, at the first Oscars in 1929 with "Wings" and for 1932's "Grand Hotel."

Asked backstage at the SAG Awards what might happen when the Oscar winners are announced Feb. 24, Affleck said: "I don't do handicapping or try to divine what's going to happen down the road with movies.

"I didn't get nominated as a director and I thought, 'OK, that's that.' Then I remembered that I was nominated as a producer," said Affleck, who already has an original screenplay Oscar for writing 1997's "Good Will Hunting" with longtime friend Matt Damon. "Nothing may happen but it's a wonderful opportunity to be on the ride and I'm really honored."

Many of the usual suspects throughout the lengthy awards season heard their names called again Sunday night, including Daniel Day-Lewis as best actor for his intense, deeply immersed portrayal of the 16th U.S. president in "Lincoln." Accepting the prize on stage, he gave thanks to several of his colleagues including "The Master" star Joaquin Phoenix (who did not receive a SAG nomination), Leonardo DiCaprio and Liam Neeson.

Backstage, Day-Lewis elaborated for reporters that DiCaprio urged him to stick with Steven Spielberg's project, which was in the works for many years.

"He said, 'Don't give up, he's the greatest man of the 19th century,'" Day-Lewis said. "So this is all Leo's fault."

His co-star, Tommy Lee Jones, also won again in the supporting-actor category for his lacerating portrayal of abolitionist Thaddeus Stevens in Spielberg's Civil War epic.

Anne Hathaway, the front-runner for best supporting actress at the Oscars and a winner already at the Golden Globes, won at the SAGs for her performance as the doomed prostitute Fantine in the gritty musical "Les Miserables."

"I'm just thrilled I have dental," Hathaway joked on stage.

But in the already-tight best actress race, Jennifer Lawrence made things a little more interesting in winning for the drama "Silver Linings Playbook." The 22-year-old plays a damaged young widow opposite Bradley Cooper, whose character is fresh out of a mental institution. Jessica Chastain, the winner at the Golden Globes, has been her main competition as a driven CIA operative searching for Osama bin Laden in "Zero Dark Thirty."

Lawrence said on stage that she got her SAG card at 14 — which was only eight short years ago — for a promo for the MTV reality series "My Super Sweet 16," which she said felt like the best day of her life.

"And now I have this naked statue which means that some of you even voted for me, and that is an indescribable feeling," she said.

On the television side, the popular PBS series "Downton Abbey" bested more established shows like "Mad Men" to win the TV drama cast award in just its first nomination. "Modern Family" won the comedy cast prize for the third straight year.

And Dick Van Dyke received the guild's life-achievement award, an honor he presented last year to his "The Dick Van Dyke Show" co-star, Mary Tyler Moore.

After receiving a lengthy standing ovation from the audience, he asked his fellow actors, "Aren't we lucky that we found a line of work that doesn't require growing up?"

____

Contact AP Movie Writer Christy Lemire through Twitter: http://twitter.com/christylemire

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Well: Keeping Blood Pressure in Check

Since the start of the 21st century, Americans have made great progress in controlling high blood pressure, though it remains a leading cause of heart attacks, strokes, congestive heart failure and kidney disease.

Now 48 percent of the more than 76 million adults with hypertension have it under control, up from 29 percent in 2000.

But that means more than half, including many receiving treatment, have blood pressure that remains too high to be healthy. (A normal blood pressure is lower than 120 over 80.) With a plethora of drugs available to normalize blood pressure, why are so many people still at increased risk of disease, disability and premature death? Hypertension experts offer a few common, and correctable, reasons:

¶ About 20 percent of affected adults don’t know they have high blood pressure, perhaps because they never or rarely see a doctor who checks their pressure.

¶ Of the 80 percent who are aware of their condition, some don’t appreciate how serious it can be and fail to get treated, even when their doctors say they should.

¶ Some who have been treated develop bothersome side effects, causing them to abandon therapy or to use it haphazardly.

¶ Many others do little to change lifestyle factors, like obesity, lack of exercise and a high-salt diet, that can make hypertension harder to control.

Dr. Samuel J. Mann, a hypertension specialist and professor of clinical medicine at Weill-Cornell Medical College, adds another factor that may be the most important. Of the 71 percent of people with hypertension who are currently being treated, too many are taking the wrong drugs or the wrong dosages of the right ones.

Dr. Mann, author of “Hypertension and You: Old Drugs, New Drugs, and the Right Drugs for Your High Blood Pressure,” says that doctors should take into account the underlying causes of each patient’s blood pressure problem and the side effects that may prompt patients to abandon therapy. He has found that when treatment is tailored to the individual, nearly all cases of high blood pressure can be brought and kept under control with available drugs.

Plus, he said in an interview, it can be done with minimal, if any, side effects and at a reasonable cost.

“For most people, no new drugs need to be developed,” Dr. Mann said. “What we need, in terms of medication, is already out there. We just need to use it better.”

But many doctors who are generalists do not understand the “intricacies and nuances” of the dozens of available medications to determine which is appropriate to a certain patient.

“Prescribing the same medication to patient after patient just does not cut it,” Dr. Mann wrote in his book.

The trick to prescribing the best treatment for each patient is to first determine which of three mechanisms, or combination of mechanisms, is responsible for a patient’s hypertension, he said.

¶ Salt-sensitive hypertension, more common in older people and African-Americans, responds well to diuretics and calcium channel blockers.

¶ Hypertension driven by the kidney hormone renin responds best to ACE inhibitors and angiotensin receptor blockers, as well as direct renin inhibitors and beta-blockers.

¶ Neurogenic hypertension is a product of the sympathetic nervous system and is best treated with beta-blockers, alpha-blockers and drugs like clonidine.

According to Dr. Mann, neurogenic hypertension results from repressed emotions. He has found that many patients with it suffered trauma early in life or abuse. They seem calm and content on the surface but continually suppress their distress, he said.

One of Dr. Mann’s patients had had high blood pressure since her late 20s that remained well-controlled by the three drugs her family doctor prescribed. Then in her 40s, periodic checks showed it was often too high. When taking more of the prescribed medication did not result in lasting control, she sought Dr. Mann’s help.

After a thorough work-up, he said she had a textbook case of neurogenic hypertension, was taking too much medication and needed different drugs. Her condition soon became far better managed, with side effects she could easily tolerate, and she no longer feared she would die young of a heart attack or stroke.

But most patients should not have to consult a specialist. They can be well-treated by an internist or family physician who approaches the condition systematically, Dr. Mann said. Patients should be started on low doses of one or more drugs, including a diuretic; the dosage or number of drugs can be slowly increased as needed to achieve a normal pressure.

Specialists, he said, are most useful for treating the 10 percent to 15 percent of patients with so-called resistant hypertension that remains uncontrolled despite treatment with three drugs, including a diuretic, and for those whose treatment is effective but causing distressing side effects.

Hypertension sometimes fails to respond to routine care, he noted, because it results from an underlying medical problem that needs to be addressed.

“Some patients are on a lot of blood pressure drugs — four or five — who probably don’t need so many, and if they do, the question is why,” Dr. Mann said.

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Little Change on Wall Street

Wall Street stocks opened flat on Monday despite strong economic data and earnings results from Caterpillar, after a rally last week that took the Standard & Poor’s 500-stock index above 1,500 for the first time in more than five years.

The S.&P. 500 was off about a point in early trading, the Dow Jones industrial average gained 4 points, and the Nasdaq composite index added 0.1 percent.

Caterpillar, a Dow component, rose 2.5 percent after it reported adjusted fourth-quarter earnings that beat expectations, though revenue was slightly below forecasts. The heavy machinery maker also said it remained cautious on the economy despite recent improvements.

“You can’t find more of a global bellwhether than Cat, and people are pleased with the number, which suggests there could be less concern about slowing growth in China after this,” said Wayne Kaufman, chief market analyst at John Thomas Financial in New York.

Thomson Reuters data through Friday showed that of the 147 S.&P. 500 companies that have reported earnings so far, 68 percent exceeded expectations. Since 1994, an average of 62 percent of companies have topped expectations, while the average over the past four quarters stands at 65 percent.

A strong start to the earnings season has bolstered equities, with major averages rising for four straight weeks. The S.&P. has gained for eight straight days, its longest winning streak in eight years, and closed at its highest since Dec. 10, 2007. The Dow ended at its highest since Oct. 31, 2007.

The S.&P. 500 is about 4.1 percent away from its all-time closing high of 1,565.15 on Oct. 9, 2007.

The Commerce Department said Monday that orders for durable goods jumped 4.6 percent in December, a pace that far outstripped expectations for a rise of 1.8 percent.

“We continue to have a parade of better-than-expected economic reports. All in all, it’s a good picture. I think there’s a good chance we’ve reached a point of recognition where people don’t think the economy will crater,” Mr. Kaufman said.

In addition to a push from earnings, equities have also risen on an agreement in Washington to extend the government’s borrowing power. On Monday, Fitch Ratings said that agreement removed the near-term risk to the country’s AAA rating. Previously, the agency said the lack of an agreement would prompt a review of the sovereign rating.

Keryx Biopharmaceuticals said a late-stage trial of its experimental kidney disease drug met the main study goal of reducing phosphate levels in blood, sending shares up 41 percent.

In Europe, stocks were generally ahead in afternoon trading.

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French Troops in Mali Push On to Timbuktu

PARIS — Mali forces backed by French troops were advancing Sunday toward the crucial northern town of Timbuktu as they begin to deploy in the rebel stronghold of Gao, French officials said.

French Prime Minister Jean-Marc Ayrault said in a statement that the French troops were “around Gao and soon near Timbuktu,” further west. Timbuktu has been under the control of rebels and Islamist fighters for 10 months, though there are reports that many of the Islamist fighters have moved farther into the vast desert.

The French are also expected to move on the large town further to the north, Kidal, with the notion of clearing population centers and garrisoning them with allied African troops before the rains are scheduled to come in March.

The capture of the main strategic points on Saturday in Gao represented the biggest prize yet in the battle to retake the northern half of the country. The French Defense Ministry spokesman, Col. Thierry Burkhard, said on Sunday morning on Europe 1 radio that Malian, Nigerian and Chadian troops were now deploying in Gao after French special forces took the Gao airport and a strategic bridge on Saturday.

“The taking of control of Gao, which has between 50,000 and 60,000 inhabitants, by Malian, Chadian and Nigerian soldiers, is under way,” Colonel Burkhard said. French airstrikes had been pounding Gao since France joined the fight at Mali’s request on Jan. 11.Gao, 600 miles northeast of Bamako, the capital, had been under the control of the Movement for Oneness and Jihad in West Africa, a splinter group of Al Qaeda in the Islamic Maghreb. Al Jazeera broadcast a statement from Al Qaeda in the Islamic Maghreb in which the group said it had withdrawn temporarily from some cities it held, but would return with greater force.

In Washington, the Pentagon said Saturday that the United States would provide aerial refueling for French warplanes. The decision increases American involvement, which until now had consisted of transporting French troops and equipment and also providing intelligence, including satellite photographs.

Little information has come from the other two main cities under rebel control — Timbuktu, the fabled desert oasis, and Kidal, northeast of Gao — for the past 10 days because mobile phone networks have been down.

Konna was overrun by Islamic fighters on Jan. 10, prompting France to intervene, and a clearer picture has begun to emerge of the fighting. Residents and officials said that at least 11 civilians had been killed in French airstrikes.

Charred husks of pickup trucks lined the road into the town, and broken tanks and guns littered the fish market, where the rebels appeared to have set up a temporary base.

Because of France’s sudden entry into the fray, the United Nations and the regional trade bloc known as Ecowas, the Economic Community of West African States, have been scrambling to put together an African-led intervention force that has been in the planning stages. The Mali Army, which has struggled to fight the Islamist groups, has been accused of serious human rights violations.

From Konna, it is easy to see why the Malian government pleaded for French help after the Islamist fighters took control of the town. Just 35 miles of asphalt separate Konna from the garrison town of Sévaré, home to the second-biggest airfield in Mali and a vital strategic point for any foreign intervention force.

Residents said their town fell to the rebels when 300 pickup trucks of fighters, bristling with machine guns, rolled in and pushed back the Malian Army troops who had been guarding the town after a fierce battle.

Amadou Traore, 29, a tire repairman, said residents had heard that the Islamist rebels had surrounded the town before the attack, but he had been confident that the army would keep them at bay.

“We thought there was no way for them to enter into the town,” he said. “But they came in the night. They told us, ‘Tomorrow we will go to Sévaré.’ ”

A woman who lived in his compound was hit by a bullet, he said. They tried to take her to the town clinic, but the doctor had fled. “After two days, she died,” Mr. Traore said.

Baro Coulibaly fled her house along the main road into town, moving with her husband and six children to the relative safety of the town center, where they stayed with her in-laws for days. They heard French bombs and rebel bullets ricocheting around the mud-walled dwellings.

“Nobody could get in or out,” Ms. Coulibaly said. “We were so afraid we barely ate or slept.”

Residents said they heard that the fearsome Tuareg leader of the Islamist group Ansar Dine, Iyad ag Ghali, had led the attack on their town, but no one saw him. The rebels spoke many languages, the residents said. Some were light-skinned Arabs and Tuaregs, a nomadic people, while others were dark-skinned people who spoke the local languages of Niger, Nigeria and Mali.

Boubacar Diallo, a local political leader, said that only a few rebel fighters came at first. Later, hundreds more joined them, overwhelming the Malian soldiers based here. He said he never saw them pray and scoffed at their assertion that they would teach the Muslim population a purer form of Islam.

“They say they are Muslims, but I don’t know any Muslim who does not pray,” Mr. Diallo said.

The fighters took down the Malian flag and raised a banner of their own, a white piece of paper printed with words in Arabic — “Assembly for the Spiritual Ideology to Purify the African World” — and pictures of machine guns.

After the Islamist fighters fled, Mr. Diallo took it down and replaced it with the Malian flag.

Lydia Polgreen reported from Konna, and Steven Erlanger from Paris. Elisabeth Bumiller contributed reporting from Washington and Scott Sayare from Paris

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'Argo' wins Producers Guild Awards

LOS ANGELES (AP) — "Argo" continues to shake up the Oscar race by taking the top honor at the Producers Guild Awards on Saturday.

Ben Affleck, coming off winning Golden Globe Awards for best motion picture drama and director for the real-life drama, received the award handed out at the Beverly Hilton Hotel.

"I'd be remiss if I didn't mention that I'm still working as an actor," he said in his acceptance speech.

Affleck also stars in "Argo" as the CIA operative who orchestrated a daring rescue of six American embassy employees during the 1979 Iranian hostage crisis. George Clooney and Grant Heslov share the producer award with Affleck as "Argo" beat out the Civil War saga "Lincoln," which has a leading 12 Academy Awards nominations.

Other nominees in the PGA movie category were "Les Miserables," ''Zero Dark Thirty," ''Beasts of the Southern Wild," ''Django Unchained," ''Life of Pi," ''Moonrise Kingdom," ''Silver Linings Playbook," and Skyfall."

Along with honors from other Hollywood professional groups such as actors, directors and writers guilds, the producer prizes have become part of the preseason sorting out contenders for Academy Awards.

The big winner often goes on to claim the best-picture honor at the Oscars on Feb. 24.

Disney's "Wreck-It Ralph" won the guild's animation category, beating "Brave," ''Frankenweenie," ''ParaNorman" and "Rise of the Guardians."

"Searching for Sugar Man" took the documentary prize, beating "A People Uncounted," ''The Gatekeepers," ''The Island President," and "The Other Dream Team."

Showtime's "Homeland" won the producer's award for television drama series, which beat out "Breaking Bad," ''Downton Abbey," ''Game of Thrones," and "Mad Men."

The ABC sitcom "Modern Family" took the prize for best comedy series for the third straight year, beating "30 Rock," ''The Big Bang Theory," ''Curb Your Enthusiasm," and "Louie."

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Well: Ask Well: Squats for Aging Knees

You are already doing many things right, in terms of taking care of your aging knees. In particular, it sounds as if you are keeping your weight under control. Carrying extra pounds undoubtedly strains knees and contributes to pain and eventually arthritis.

You mention weight training, too, which is also valuable. Sturdy leg muscles, particularly those at the front and back of the thighs, stabilize the knee, says Joseph Hart, an assistant professor of kinesiology and certified athletic trainer at the University of Virginia, who often works with patients with knee pain.

An easy exercise to target those muscles is the squat. Although many of us have heard that squats harm knees, the exercise is actually “quite good for the knees, if you do the squats correctly,” Dr. Hart says. Simply stand with your legs shoulder-width apart and bend your legs until your thighs are almost, but not completely, parallel to the ground. Keep your upper body straight. Don’t bend forward, he says, since that movement can strain the knees. Try to complete 20 squats, using no weight at first. When that becomes easy, Dr. Hart suggests, hold a barbell with weights attached. Or simply clutch a full milk carton, which is my cheapskate’s squats routine.

Straight leg lifts are also useful for knee health. Sit on the floor with your back straight and one leg extended and the other bent toward your chest. In this position, lift the straight leg slightly off the ground and hold for 10 seconds. Repeat 10 to 20 times and then switch legs.

You can also find other exercises that target the knees in this video, “Increasing Knee Stability.”

Of course, before starting any exercise program, consult a physician, especially, Dr. Hart says, if your knees often ache, feel stiff or emit a strange, clicking noise, which could be symptoms of arthritis.

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J. Richard Hackman, an Expert in Team Dynamics, Dies at 72

J. Richard Hackman, a Harvard psychology professor whose fieldwork sometimes took him to the cockpit of an airliner to observe the crew in a nearly five-decade quest to determine the dynamics of teamwork and effective leadership, died on Jan. 8 in Boston. He was 72.

The cause was lung cancer, his wife, Judith Dozier Hackman, said.

Dr. Hackman, the author or co-author of 10 books on group dynamics, was the Edgar Pierce professor of social and organizational psychology at Harvard.

In one of his best-known books, “Leading Teams: Setting the Stage for Great Performances” (2002), he replaced the popular image of the powerful “I can do it all” team leader with that of someone who, as he wrote, had the subtle skills “to get a team established on a good trajectory, and then to make small adjustments along the way to help members succeed.”

The conditions for a successful team effort — among them “a compelling direction, an enabling team structure, a supportive organizational context and expert team coaching” — “are easy to remember,” Dr. Hackman wrote.

“The challenge,” he continued, “comes in developing an understanding of those conditions that is deep and nuanced enough to be useful in guiding action, and in devising strategies for creating them even in demanding or team-unfriendly organizational circumstances.”

Besides tracking the interplay of pilots, co-pilots and navigators aboard civilian and military planes, Dr. Hackman observed corporate boards, sports teams, orchestra players, telephone-line repair crews, hospital workers and restaurant kitchen staff members.

And in recent years, for his 2011 book, “Collaborative Intelligence,” he was allowed to observe interactions within the American intelligence, defense, law-enforcement and crisis-management communities.

“Although my main aspiration has been to provide guidance that will be useful to team leaders and members,” he wrote, “there are no ‘one-minute’ prescriptions here — creating, leading and serving on teams is not that simple.”

Anita Woolley, a professor of organizational behavior and theory at the Tepper School of Business at Carnegie Mellon University in Pittsburgh, said, “The key thing about Dr. Hackman’s work is that it stands in contrast to some of the more popular models of leadership that focused very much on style or how leaders behave, versus what they do.”

Rather than viewing pay as a prime motivator for good performance, she continued, “he focused on features of people’s jobs that made them more intrinsically satisfied: the freedom to determine how they conduct their work, having a variety of tasks, having knowledge of the ultimate outcomes of their work, knowing how their work affects or is received by other people.”

He also liked to overturn some of the received wisdom about teamwork. In a 2011 article for The Harvard Business Review, Dr. Hackman listed “Six Common Misperceptions About Teamwork.” Among them was this:

“Misperception No. 2: It’s good to mix it up. New members bring energy and fresh ideas to a team. Without them, members risk becoming complacent, inattentive to changes in the environment, and too forgiving of fellow members’ misbehavior.

“Actually: The longer members stay together as an intact group, the better they do. As unreasonable as this may seem, the research evidence is unambiguous. Whether it is a basketball team or a string quartet, teams that stay together longer play together better.”

John Richard Hackman was born in Joliet, Ill., on June 14, 1940, the only child of J. Edward and Helen Hackman. His father was an oil pipeline engineer, his mother a schoolteacher.

Dr. Hackman received a bachelor’s degree in mathematics from MacMurray College in Jacksonville, Ill., in 1962, and a doctorate in psychology from the University of Illinois in 1966. He soon joined the psychology and administrative sciences department faculties at Yale, where he taught until 1986, when he moved to the psychology and business departments at Harvard.

Besides his wife, who is an associate dean at Yale, he is survived by two daughters, Julia Beth Proffitt and Laura Dianne Codeanne, and four grandchildren.

After Dr. Hackman died, The Harvard Crimson wrote that for years he had “devoted countless hours to improving one team in particular — the Harvard women’s basketball squad, for which he volunteered as an honorary coach.”

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